摘要：目的  探讨了慢性肾炎患者血清HCY、APN、BNP水平的变化及临床意义。方法  采用免疫化学法和化学发光免疫法检测31例慢性肾炎和30例健康人血清HCY、APN和BNP水平。结果  慢性肾炎患者HCY、BNP水平高于对照组,差异具有统计学意义（P<0.01），而APN水平低于对照组，差异具有统计学意义（P<0.01），血清HCY水平与BNP水平呈正相关（r=0.6018,P<0.01），而与APN水平呈显著负相关（r=-0.5082,P<0.01）。结论  联合检测血清HCY、APN和BNP水平的变化对疾病的诊断和治疗有重要的临床价值。

Abstract：Objective To explore the clinical significance of serum homocysteine (Hcy), adiponectin (APN) and B-type natriuretic peptide (BNP) in patients with chronic nephritis. Methods The serum levels of Hcy, APN and BNP in 31 patients with chronic nephritis and 30 health controls were measured by immune method and CLIA. Results The serum Hcy, BNP levels in patients with chronic nephritis were significantly higher than those in controls, but the serum APN level was lower than those in controls (P<0.01). The serum Hcy levels were positively correlated with serum BNP (r=0.6018, P<0.01) and negatively correlated with APN levels (r=-0.5802, P<0.01). Conclusion The combined detection of serum Hcy, APN and BNP levels changes might have clinical values in the diagnosis and treatment of patients with chronic nephritis.