目的 探究妊娠期单纯性低甲状腺激素血症对妊娠结果是否有不良影响。方法 对112例诊断为妊娠期单纯性低甲状腺激素血症妇女和112例甲状腺功能正常妊娠妇女就多种因素进行比较。结果 观察组和对照组两组之间就年龄、既往生育史、吸烟史、妊娠期感染史、妊娠期服药史等可能影响因素比较，发现其对妊娠结果无明显影响；两组间血清三碘甲状腺原氨酸（FT3）、促甲状腺激素（TSH）相比较，差异均无统计学意义；观察组与对照组平均血清甲状腺素水平分别为9.3±0.9μg/L、13.9±0.8μg/L，两组之间差异具有统计学意义（P<0.05）。在两组当中妊娠期间均未观察到流产、先兆子痫、胎盘早剥、早产等妊娠并发症。观察组新生儿出生时出平均出生体重值为3.2±0.2kg、平均身长49±1.3cm、平均头围33±1.7cm、新生儿评分（Apgar评分）平均值 9.4±0.2，对照组新生儿平均出生体重3.0±0.3kg、平均身长50±0.9cm、平均头围34±0.9cm）、Apgar评分平均值 9.3±0.4，两组之间差异均无统计学意义。结论 本研究发现妊娠期单纯性低甲状腺激素血症对妊娠没有不良影响。

Objective To explore the outcomes and adverse effects of isolated hypothyroxinemia in pregnant women. Methods 112 cases of diagnosed isolated hypothyroxinemia (observation group) and 112 euthyroid pregnant women (control group) in pregnancy period were selected. The thyroid function indexes were determined and the pregnancy outcomes were analyzed. Results There were no statistical differences on pregnancy outcomes related to age, previous reproductive history, history of diabetes mellitus, HbA1C, history of thyroid disease between two groups. There were no statistical differences in serum FT3 and TSH levels between two groups. The mean serum FT4 level in observation and control group were 9.3±0.9 μg/L and 13.9±0.8 μg/L respectively and with significant differences (P<0.05). There were no abortion, preeclampsia, premature birth observed in both groups during the pregnancy. Conclusion The isolated hypothyroxinemia has no any adverse effects on pregnancy outcome.