摘要：目的 调查深圳市第二人民医院就诊的甲状腺癌患者的患病特点，分析并找出与甲状腺癌发病率相关的潜在危险因子。明确甲状腺癌与碘营养之间的相关性，为合理的碘摄入以及甲状腺癌的防治工作提供科学依据。方法 采取连续收录与分层抽样的方法, 收集2013年2月至2014年12月于深圳市第二人民医院核医学科甲状腺病门诊就诊的甲状腺癌患者123例，结节性甲状腺肿组患者150例及正常对照组102例；测定尿碘含量；采集血样检测甲状腺功能；并完成相关的情绪压力、焦虑及生活方式等问卷调查。结果 患者婚姻状态、教育程度、居住地区、情绪焦虑评分、T4、TSH 6个变量有统计学意义(P<0.05)，提示这6个变量可能与甲状腺癌患病相关； 患者血脂高（高脂血症）、BMI体重指数与甲癌可能有相关，相关性接近有统计学差异；而患者尿碘浓度与甲癌患病显示无显著相关性（P=1.65）。结论 本研究中收录的患者甲状腺癌的发生率与尿碘水平无明显相关性；而与患者肥胖、婚姻状况等生活方式因素以及情绪焦虑相关。

Abstract: Objective In the last few decades, the incidence of thyroid cancer has been found rapidly increased worldwide as well as in China. It is suspected that this increasing might be related to the iodine over-intake since the introduction of USI. However, the results were of inconsistence, and we aim to look into this relationship in Shenzhen. Methods A total of 123 patients with diagnosis of thyroid cancer (TC) and 150 patients with nodular goiter were consecutively recruited while 102 normal subjects were randomly selected as control group in comparing the urine Iodine levels. The thyroid hormones, thyroid autoantibodies in serum were also measured. Life-style and social economic factors were collected. Anxiety and stress were scored by questionnaires and compared among the three groups. Results There was no significant difference between the TC group, nodular goiter group and control group in terms of urine iodine levels (120.2±118.9μg/L, 128.5±136μg/L vs. 124.5±124μg/L; F=0.32, P=0.572). Multiple regression analysis indicated that the thyroid cancer incidence was significantly associated with patient’s marital status, education levels, higher BMI (P<0.05) and anxiety scores. Conclusion Incidence of thyroid cancer is not significant associated with patient’s urine Iodine level but associated with the life-style factors such as obesity, divorce, education and anxiety.