目的：通过研究妊娠期妇女血清中甲状腺指标的变化情况，探讨甲功检测在妊娠妇女中的应用价值。方法：应用化学发光分析仪对747例早中期妊娠妇女（实验组）和593例非妊娠育龄妇女（对照组）血清中的甲功五项（血清三碘甲状腺原氨酸（triiodothyronine，T3）、甲状腺素（thyroxin，T4）、血清促甲状腺素（thyrotropin ，TSH）、游离三碘甲状腺氨酸（free triiodothyronine，FT3）以及游离甲状腺素（free thyroxine，FT4））进行检测，比较两组结果的差异，同时分析TSH与人绒毛膜促性腺激素（human chorionic gonadotropin，HCG）结果的相关性。结果 ①747份妊娠期妇女血清，甲状腺功能检查指标有异常的254份，异常率为34.09％，593份对照组血清，指标异常98份，异常率16.53%，异常率差异有统计学意义(P<0.05)；②妊娠期妇女TSH水平低于对照组，TT3和TT4高于对照组，差异有统计学意义(p<0.05)，而FT3、FT4两组差异无统计学意义(P>0.05);③TSH水平与同期HCG水平呈负相关，r=-0.527(P<0.05)，同时TSH异常低值组HCG水平（16.22×104±4.34 ×104mIU/mL）明显高于TSH正常组（7.83×104 ±5.30×104mIU/mL），差异有统计学意义(P<0.05)。结论：妊娠期妇女甲状腺功能异常率升高明显，应加强其甲状腺功能的监测，同时注意高浓度HCG对TSH检测结果的影响。

Objective To investigate the changes and clinical value of thyroid functional levels in pregnant woman. Methods The five thyroid functional indexes, triiodothyronine (TT3), thyroxin (TT4), thyrotropin (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) in 747 early and midtrimester pregnancy women (experimental group) and 593 un-pregnancy reproductive age women (control group) were detected by using chemiluminescent analyzer. The association between TSH and human chorionic gonadotropin (HCG) was analyzed. Results The abnormal rate of thyroid functional indexes in experimental group was significantly higher than that in control group (P<0.05). The serum level of TSH in experimental group was significantly lower, and the serum levels of TT3 and TT4 were higher than that of in control group (P<0.05). However, there were no significantly difference in serum FT3 and FT4 between the two groups (P>0.05). The level of TSH was negatively related with HCG (r=-0.527, P<0.05). The serum level of HCG in the women with abnormally lower TSH was significantly higher than in that with normal TSH women (P<0.05). Conclusion It is necessary to enhance monitoring the thyroid function of pregnant woman due to the higher abnormal rate, and more attention should be paid on the effect of high density HCG to TSH.