目的探讨对于临床确诊为结直肠癌患者采用腹腔镜手术较传统开放手术的免疫和生理反应方面的影响。方法 选取2013年6月至2014年6月经临床确诊为结直肠癌并于我院消化外科采用腹腔镜手术治疗的50例患者为观察组，同期采用传统开腹手术进行治疗的50例患者为对照组，比较分析两组患者的免疫和生理反应的变化。结果 与对照组比较，术后7天CD4/CD3、术后3天IgM在观察组中升高、术后3天IL-6和CPR在观察组中降低，差异具有统计学意义（P<0.01）；与对照组比较，术后7天TNF-α在观察组中降低，差异具有统计学意义（P<0.05）。在生理功能的比较中，观察组患者在胃动素和胃泌素的分泌方面优于对照组，差异具有统计学意义（P<0.05）。结论 因腹腔镜手术对患者的免疫和生理功能的损伤小，更有利于健康的恢复，值得在临床上推广使用。

Objective To investigate the effect of laparoscopic and traditional open operation on immune and physiological responses of patients with colorectal cancer. Methods 50 patients clinically diagnosed for colorectal cancer and digestive surgery by laparoscopic operation and 50 cases of colorectal cancer patients with traditional open operation were chosen as the observation group and control group. The changes of comparative analysis of immune and physiological responses of two groups of patients were carried out. Results Compared with control group, the content of CD4/CD3 in observation group at 7 days after operation and IgM levels after 3 days were increase and the serum levels of IL-6 and CPR were decreased (P<0.01). The TNF-alpha levels in observation group at 7 days after operation were decreased (P<0.05). The motilin and gastrin secretion in observation group were better than that of in the control group (P<0.05). Conclusion The laparoscopic surgery with less damage on immune and physiological function of patients with colorectal cancer is much more conducive to the recovery of health and it is worth for widely clinical application.