目的 研究E-选择素在生殖道沙眼衣原体感染中的作用。方法 将64只小鼠生殖道沙眼衣原体感染模型随机分成2组，实验组中的小鼠用人工合成E-选择素干预，对照组中的小鼠用生理盐水进行干预，统计两组在1w，2w，3w，4w不同时间点上的感染小鼠阴道脱落菌量以及沙眼衣原体感染率。结果 成功建立生殖道沙眼衣原体感染的小鼠模型：与对照组相比较，人工合成E-选择素干预后1w和2w的生殖道沙眼衣原体感染率（90.2% vs 77.4%,85.3% vs 70.1%）显著增高，而阴道脱落菌量显著增高（4.758±0.225 vs 3.210±0.315， 2.698±0.177 vs 1.809±0.203），两组具有统计学差异。在干预后3w两组的沙眼衣原体感染率分别为34%和24%，阴道脱落菌量分别为1.412±0.134和1.201±0.189，两组无显著差异性；两组在干预后4w的沙眼衣原体感染率均为0以及无阴道脱落菌量。结论 E-选择素能促进生殖道沙眼衣原体感染的发生率以及增加沙眼衣原体的毒力，有望为进一步阐明生殖道沙眼衣原体感染的发病机制提供实验依据。

Objective To investigate the effect of E-selectin on genital chlamydia trachomatis infection. Methods 64 cases of mice infected by chlamydia trachomatis were divided randomly into two groups: the experiment group and the control group. Mice in the control group were treated with saline, and those in the experiment group with artificial synthesized E-selectin. At 1, 2, 3 and 4 weeks after intervention, the chlamydia trachomatis infection rate and the chlamydial shedding were calculated. Results Mice model of genital chlamydia trachomatis infection was successfully made. The chlamydia trachomatis infection rate at 1 and 2 weeks in the experiment group were higher (90.2%, 85.3%) than those in the control group (77.4%, 70.1%). The chlamydial shedding were lower in the experiment group (2.458±0.225, 1.198±0.177) than those in the control group (3.210±0.315，1.809±0.203). There was statistically significant difference. between the two groups There were not any significant differences among two groups at 3 weeks after intervention in the term of the infection rate (34% vs 24%) and chlamydial shedding (0.912±0.134 vs 1.201±0.189). There was no infection and chlamydial shedding in mice of two groups at 4 weeks after intervention. Conclusion E-selectin can facilitate the genital track infection from chlamydia trachomatis, which could provide the foundation for further illuminating the pathogenesis of genital chlamydia trachomatis infection.