目的 探讨血浆脑利钠肽和超敏C反应蛋白对急性缺血性脑卒中患者3个月预后的评估价值。方法 收集本院确诊为急性缺血性脑卒中患者114例。随机选取52例恢复良好患者和24例恢复较差患者用于建立区分模型，其余26例恢复良好和12例恢复较差患者用于验证模型。建模组和验证组中的恢复良好组和恢复较差组年龄和性别均无统计学差异（P<0.05）。分别检测这些患者血浆脑利钠肽和超敏C反应蛋白的含量，并利用受试者工作特征曲线评价其价值。结果 神经功能恢复良好组和恢复较差组之间的吸烟、饮酒、高血压、高血糖和高血脂这些危险因素的差异无统计学意义（P>0.05）；脑利钠肽和超敏C反应蛋白含量在两组之间的差异具有统计学意义（P<0.05）；将两者联合分析后，其曲线下面积为0.86（0.79，0.93），敏感性和特异性分别为84.61%和79.17%；验证后，其诊断敏感性和特异性分别为80.77%和75.00%。结论 联合使用脑利钠肽和超敏C反应蛋白可以为急性缺血性脑卒中患者3个月预后的评估提供一种潜在的辅助方法。

Objective To investigate the value of serum brain natriuretic peptide and high sensitivity C-reactive protein in the prognosis of acute ischemic stroke patients after 3 months. Methods 114 acute ischemic stroke patients were collected in our hospital. 52 good recovery patients and 24 poor recovery patients were randomly selected for the model building, and the remaining 26 good recovery patients and 12 poor recovery patients were used for the model validating. In the training group and validation group, the sex and age of good recovery group and poor recovery group showed no significant difference. Plasma brain natriuretic peptide and high-sensitivity C-reactive protein levels were detected in all samples, and receiver operating characteristic curve was used to evaluate their diagnostic value. Results The risk factors including smoking, drinking, high blood pressure, high blood sugar and high cholesterol showed no significant difference between the good recovery group and poor recovery group (P>0.05). There were significant difference on the brain natriuretic peptide and high-sensitivity C-reactive protein levels between the two groups (P<0.05). When combined analysis brain natriuretic peptide and high-sensitivity C-reactive protein, the area under the curve was 0.86 (0.79, 0.93), the sensitivity and specificity were 84.61% and 79.17%, separately. After validation, the diagnostic sensitivity and specificity were 80.77% and 75%, separately. Conclusion The combined detection of brain natriuretic peptide and high-sensitivity C-reactive protein may provide an effective potential method to assess the 3 months prognosis of acute ischemic stroke patients.