目的 检测慢性阻塞性肺疾病（COPD）患者血清甲状腺激素水平的变化，并分析其临床意义。方法 应用化学发光微粒子免疫分析方法检测84例住院COPD患者急性发作时和好转出院2周后血清中TT3、TT4、FT3、FT4、高敏促甲状腺激素（sTSH），并与60名健康志愿者的甲状腺激素水平相互比较。结果 COPD患者的TT3、TT4、FT3、FT4水平明显低于对照组，sTSH高于对照组。在COPD组中TT3、FT3低于正常值的比例明显高于TT4和FT4。COPD患者出院2周后的甲状腺激素水平有一定程度的升高，但仍低于对照组。结论 COPD患者的甲状腺激素水平发生变化，多数表现为低T3综合征，可通过检测激素水平指导COPD患者的治疗和预测预后。

Objective To observe the changes of serum thyroid hormone levels in patients with chronic obstructive pulmonary disease (COPD) and to analysis its clinical significance. Methods The serum levels of TT3, TT4, FT3, FT4 and sTSH in 84 COPD in-patients and 60 healthy volunteer controls were detected at on admission and two weeks after discharged by chemiluminesent microparticle immunoassay method. Results The serum levels of TT3, TT4, FT3 and FT4 were significantly lower in COPD patients than those in controls. On the contrary, the serum sTSH level in COPD patients was higher than that of controls. The ratio of abnormal TT3 and FT3 levels in the COPD group were higher than that of TT4 and FT4. The serum TT3, TT4, FT3 and FT4 levels in the COPD group were higher than those in AECOPD patients. Conclusion The changes of thyroid hormone level of COPD patients always show low-T3 syndrome. The hormone level changes may be used to guide the treatment and predict prognosis of COPD patients.