目的 通过测定早期肥胖相关性肾病患者的血清胱抑素C水平，探讨其与尿白蛋白排泄的关系。方法 选择在我院住院治疗的肥胖相关性肾病患者30例,门诊就诊的单纯肥胖者20例,以我院体检中心30名健康体检者作为对照者。采用免疫比浊法测定入选者血清的胱抑素C水平，并应用放射免疫分析法测定尿白蛋白排泄。结果 早期肥胖相关性肾病组及单纯肥胖组血清胱抑素C水平高于对照组(P ＜0.01)，早期肥胖相关性肾病组血清胱抑素C水平与单纯肥胖组比较差异有统计学意义 (P ＜0.01)。早期肥胖相关性肾病组血清胱抑素C水平与尿白蛋白排泄呈正相关。结论 血清胱抑素C测定对肥胖相关性肾病的早期肾损伤具有重要的诊断价值。

Objective To explore the serum level of Cystatin C (CysC) and its relationship with urinary albumin excretion (UAE) in patients with obesity related glomerulopathy. Methods 30 obesity patients with early obesity related glomerulopathy and 20 obesity patients without complication were enrolled in the study. 30 health check-up individuals were selected as control group. The levels of the serum CysC and UAE were measured by nephelometry and radioimmunoassay respectively. Results The levels of serum CysC in early obesity related glomerulopathy patients were significantly higher than those of the control group (P ＜0.01). There was a significant difference on serum CysC levels between early obesity related glomerulopathy group and simple obesity group. The serum level of Cys C was positively correlated with UAE in patients with early obesity related glomerulopathy. Conclusion The serum CysC levels can be a sensitive indicator to reflect the early stage damage in patients with early obesity related glomerulopathy.