目的 探讨半乳糖凝集素3（galectin-3,gal-3）与急性缺血性脑卒中的关系及临床意义。方法 选择急性缺血性脑卒中患者165例为患者组，同期健康体检中心无脑卒中病史的健康体检者100名为对照组，采用酶联免疫吸附法（ELISA）检测gal-3；行头颅核磁共振检查计算脑梗死体积大小，按美国国立卫生研究所中风量表（NIHSS评分）进行神经功能缺损程度评估。结果 对照组血清gal-3水平（5.18±1.56μg／L）与患者组（14.57±3.35μg／L）差异有统计学意义（ t = 23.517, P＜0.01）； gal-3水平随脑梗死体积增加而呈递增趋势，差异有统计学意义（F=130.86, P＜0.01）。Spearman 相关分析显示，脑梗死体积与血清gal-3水平正相关（rs=0.927, P＜0.01）； gal-3水平随神经缺损程度增加而呈递增趋势，差异有统计学意义（F=126.53,P＜0.01）。Spearman 相关分析显示，神经缺损程度与血清gal-3水平正相关（rs=0.872, P＜0.01）。结论 急性缺血性脑卒中患者gal-3水平显著升高, 其升高程度与脑梗死体积、神经功能缺损程度相关。

Objective To explore the relationship of galectin-3 in patients with acute ischemic stroke and its and clinical significance. Methods 165 patients with acute ischemic stroke were chosen as patients group, and 100 healthy persons in healthy center without a history of stroke as control group. The levels of galectin-3 in both groups were detected by enzyme-linked immunosorbent assay (ELISA). The size of infarct volume was calculated by cranial magnetic resonance imaging (MRI) and the degree of neurological deficit was assessed according to the U.S. National institutes of health stroke scale (NIHSS scores). Results There was no statistically difference (t = 23.517, P <0.01) between serum levels in patient group (14.57 ± 3.35μg / L) and control group (5.18 ± 1.56μg / L). The galectin-3 level in patients was increased with the increasing of brain infarct volume (F=130.86 P＜0.01). The Spearman correlation analysis showed that the infarct volume was positively correlated with the serum level of galectin-3 (rs = 0.927, P<0.01). The serum level of galectin-3 was increased with the increasing of neurological deficit degree（F=126.53,P＜0.01). The degrees of neurological deficit were positively correlated with serum levels of galectin-3 (rs = 0.872, P <0.01). Conclusion The galectin-3 levels of patients with acute ischemic stroke are significantly increased and correlated with the volume of cerebral infarction and the degree of neurological deficits.