摘要： 目的 探讨降钙素原（PCT）对于脓毒症患者早期诊断的临床价值。方法：本研究纳入65例脓毒症患者，收集患者血清降钙素原（PCT）、C反应蛋白（CRP）、白细胞计数（WBC）及血培养等结果，比较细菌感染与病毒感染，革兰氏阴性菌与革兰氏阳性菌，以及不同病情程度患者组别之间PCT、CRP以及WBC水平的差异。结果 各组数据对比显示，细菌感染患者PCT水平显著高于病毒感染患者（P<0.01），G-菌感染患者PCT水平显著高于G+菌感染患者（P<0.01），脓毒症休克患者PCT水平显著高于脓毒症或严重脓毒症患者（P<0.01），而三组别间CRP、WBC比较差异均无统计学意义。结论 降钙素原（PCT）对于鉴别脓毒症患者感染病原具有一定临床价值，并且能够有效进行脓毒症严重情况的分级，可为患者早期的临床治疗及预后评价提供有效辅助作用。

Abstract: Objective To explore the clinical value of procalcitonin (PCT) in patients with sepsis caused by different pathogens. Methods 65 patients diagnosed with sepsis were involved in this study. The test data such as serum PCT, CRP, WBC and blood culture were collected. These data from bacterial and virus groups, G+ and G- groups, sepsis, severe sepsis and sepsis shock groups were compared respectively. Results The serum PCT level in bacterial group and G- group were significantly higher than in virus group and G+ group. The serum PCT level in sepsis shock group was also significantly higher than in sepsis or severe sepsis group. No statistically significant difference was found in CRP and WBC among these groups. Conclusion Clinical benefits of using PCT to distinguish different pathogens and categorize severity of sepsis in infected patients had been proved, which might provide effective reference for clinical treatment in early stage and prognosis for sepsis.