摘要：目的 分析我院血管内导管相关性血流感染(catheter-related bloodstream infection，CRBSI)的病原菌构成及耐药分析，为临床治疗提供依据。方法 对本院2010年1月至2014年5月确诊的91例CRBSI的107株病原菌进行回顾性分析。结果 6688例患者中91例为CRBSI的确诊病例，占1.4%，主要来源于ICU、烧伤科、肾内科和急救部；107株病原菌中，革兰阳性菌占28.0%（30株），以葡萄球菌为主，其中凝固酶阴性葡萄球菌占12.1%（13株），金黄色葡萄球菌占10.2%（11株），对万古霉素、利奈唑胺和替加环素的敏感率均达100%；非发酵的革兰阴性菌占63.6%（68株），其中病原菌分离率最高的是洋葱伯克霍尔德菌、鲍曼不动杆菌和铜绿假单胞菌，分别占20.6%、12.1%和12.1%,非发酵菌的多药耐药较严重；真菌占8.4%（9株），其中白色念珠菌对氟康唑、伊曲康唑、两性霉素Ｂ、5-氟胞嘧啶均敏感，但光滑念珠菌和克柔念珠菌有不同程度的中介和耐药。结论 葡萄球菌属、非发酵革兰阴性杆菌和念珠菌属是本院CRBSI的主要病原菌，重视病原菌的监测，指导临床合理用药对控制CRBSI非常重要。

Abstract：Objective To analyze the distribution and drug resistance of pathogens causing intravascular catheter-related bloodstream infections (CRBSI), and provide doctors with laboratory evidence of CRBSI diagnosis. Methods A retrospective analysis of 107 strains of CRBSI pathogens’ distributions from 91 inpatients whose catheter culturing was positive. Results There were 91 (1.4%) patients diagnosed as CRBSI among 6688 cases. They were from ICU, Burns Branch, Department of Nephrology and Emergency Room. A total of 107 strains of pathogens, gram-positive bacteria accounted for 28% (30 strains), 12.1% (13 strains) of which were coagulase-negative Staphylococcus, 10.2% (11strains) of which were Staphylococcus aureus, the susceptibility rates to vancomycin, linezolid and tigecycline of Staphylococcus arrived at 100%, non-fermenting gram-negative bacteria accounted for 63.6% (68 strains). The first three by rank order of the CRBSI pathogens were Burkholderia cepacia (20.6%), Acinetobacter baumannii (12.1%), Pseudomonas aeruginosa (12.1%). The multi-drug resistant was more serious in non-fermenting bacteria, fungi accounted for 8.4% (9 strains), and in which Candida albicans were sensitive to fluconazole, itraconazole, amphotericin B and 5-fluorocytosine. However, C.glabrata and C.krusei had different degrees of intermediaries and antimicrobial drugs. Conclusion CRBSI’ major pathogens are Staphylococcus, non-fermenting Gram-negative bacteria and Candida species, attaching importance to pathogen and drug sensitivity inspection can guide controlling bacteria of CRBSI and rational using clinical antibiotics.