摘要：目的 探讨维生素D水平与平均血小板体积(MPV)的相关性。方法 选取患者420例测定维生素D水平及MPV。根据测得维生素D水平将病例分为组1：维生素D<10ng/mL；组2：维生素D为10～20ng/mL；组3：维生素D>20ng/mL。比较各组检测结果，分析维生素D水平与MPV变化的相关性。结果 三组维生素D水平分别为8.9±2.1ng/mL，14.3±1.7 ng/mL，24.2±5.9 ng/mL，差异有统计学意义（P<0.001）。三组患者MPV分别为8.3±1.7fL，8.0±1.4fL，7.3±1.5fL。组3与组1、组2 MPV差异有统计学意义（P<0.001；P=0.006）。维生素D水平与MPV存在负相关(r2=0.337，P<0.001)。结论 维生素D水平与MPV密切相关，维生素D的缺乏可能导致MPV升高。

Abstract: Objective To investigate the correlation between the vitamin D level and mean platelet volume (MPV). Methods 420 patients were collected. According to the vitamin D level, the patients were allocated to Group 1 (vitamin D <10ng/mL), Group 2 (vitamin D, 10-20ng/mL), Group 3 (vitamin D >20ng/mL), respectively. The vitamin D level and mean platelet volume in all patients were detected. Results The vitamin D level in Group 1 (7.7±1.9ng/mL) was lower than that in Group 2 (14.3±1.7 ng/mL, P<0.001) and Group 3 (24.2±5.9 ng/mL, P<0.001). The MPV in Group 3 (7.3±1.5 fL) was lower than that in Group 1 (8.3±1.7 fL, P<0.001) and Group 2 (8.0±1.4 fL, P =0.006). Linear regression analysis showed that low levels of vitamin D (r2=0.337，P<0.001) was independently associated with increased MPV. Conclusion The vitamin D level is closely related with MPV. The vitamin D deficiency would results in a higher MPV.