摘要：目的 探讨高强度聚焦超声(HIFU)治疗甲状腺结节的方法、安全性及近期疗效。方法 治疗组20例单发甲状腺良性实性结节行高强度聚焦超声(HIFU)治疗， 治疗后采用常规超声随访（1月、3月、6月、12月）观察结节大小、 血供，并观察并发症的发生情况及监测甲状腺功能。对照组20例单发甲状腺良性实性结节未经任何治疗，随访方法及时间与治疗组相同。结果 治疗组20例患者均成功进行了高强度聚焦超声(HIFU)治疗，术后超声随访结节的体积较术前逐渐缩小（P<0.05），血流信号消失。治疗前、后检测甲状腺功能（FT3、FT4及TSH）无明显变化（P>0.05）。对照组随访12个月结节体积及甲功均无明显变化（P>0.05）。结论 高强度聚焦超声(HIFU)是治疗甲状腺良性结节安全性高、创伤小、可控性强、疗效确切、具有临床应用潜质。

Abstract: Objective To investigate the safety and efficacy of high intensity focused ultrasound (HIFU) method in the treatment of thyroid nodules. Methods 20 cases patients with solitary benign thyroid solid nodules were treated with high intensity focused ultrasound therapy. After treatment, the nodule size and blood supply were followed-up with conventional ultrasound, and the incidence of complications were observed in the monitoring of thyroid function. A group of 20 cases with solitary thyroid nodule without any treatment were selected as control group. Results The treatment group of 20 cases were successfully carried out in high intensity focused ultrasound (HIFU) treatment, postoperative follow-up sonography nodule volume was gradually reduced (P<0.05), blood flow signals disappeared. The thyroid function before and after treatment had no significant changes (P>0.05). The control group was followed up for 6 months and thyroid nodule volume showed no significant change (P>0.05).Conclusion High intensity focused ultrasound (HIFU) is the treatment of benign thyroid nodules with high safety, less trauma, strong controllability, exact curative effect and may have a great clinical potential.