目的 探讨神经元特异性烯醇化酶（NSE）和同型半胱氨酸（HCY）联合检测在脑梗死诊断中的应用价值。方法 选择脑梗死组患者120例和正常对照组健康人120例，分别检测NSE和HCY含量，并比较分析其与脑梗死的关系。结果 脑梗死患者较正常对照组NSE和HCY的含量明显增高（P<0.05），并且有良好的相关性。脑梗死大面积组比小面积组NSE和HCY的含量均显著增高（P<0.05）。脑梗死组NSE和HCY的阳性率明显高于正常对照组，二者联合检测阳性率（91.6%）高于单独检测阳性率。结论 血清NSE和HCY联合检测在诊断脑梗死的发生发展中起一定作用，其含量可用于脑梗死患者的早期诊断、病情轻重和预后的评估。

Objective To explore the clinical value of combined detection of neuron specific enolization enzyme (NSE) and homocysteine (HCY) in the diagnosis of cerebral infarction. Methods The serum NSE and HCY levels in 120 patients with cerebral infarction and normal control were detected respectively and the results were used to analyze its relationship with cerebral infarction. Results The serum NSE and HCY levels in patients with cerebral infarction were significantly higher than that of controls (P < 0.05). The serum NSE and HCY levels in patients with large area cerebral infarction were higher than that of in smaller cerebral infarction area group (P < 0.05). The positive rate of NSE and HCY in cerebral infarction group was obviously higher than that of normal control group. The positive rate of combined detection of NSE and HCY were 91.6% and higher than that of single detection. Conclusion The combined detection of serum NSE and HCY play an important role in the diagnosis of cerebral infarction development. They can be used in the early diagnosis, the disease severity and prognosis evaluation of patients with cerebral infarction.