目的 探讨全自动生化分析仪测定尿酸（UA）时产生交叉污染的来源及避免对策。方法 筛查出对UA测定存在污染的试剂；确定干扰试剂的种类后进行试剂污染试验，检测交叉污染的情况。结果 在试剂干扰检测中发现，高密度脂蛋白胆固醇(HDL-C)测定对UA的测定存在污染；试剂污染试验发现，HDL-C对UA检测结果有明显的正干扰。结论 全自动生化分析仪测定UA会存在项目间的交叉污染，可通过调整项目检测顺序、建立试剂针特殊清洗程序，或者更换具有抗污染成分的试剂等方法避免交叉污染。

Objective To investigate the sources of cross-contamination in the determination of uric acid with automatic biochemical analyzer. Methods The contamination reagent in the determination of UA were Screened out. After determining the interference reagent, the cross-contamination tests were performed. Results In combination detection, HDL measurement had contamination in the UA measurement. The reagent contamination trial found a significant positive interference of HDL reagent to UA test results. Conclusion Automatic biochemical analyzer has cross-contamination in the determination of uric acid. The cross-contamination could be reduced and avoided by adjusting the project detection order, establishing special cleaning procedures for reagent needle, or by replacing the reagents with anti-contamination ingredients.