目的 探讨血清胱抑素C(Cysc-C)、尿微量白蛋白(UmAlb)、尿β2-MG(Uβ2-MG)检测在肝硬化患者中的应用价值。方法 应用免疫比浊法和酶联免疫法对61例肝硬化患者（其中31例无腹水，30例伴腹水）进行血清Cysc-C、UmAlb、Uβ2-MG水平检测，并与35名正常健康人做比较。结果 肝硬化患者血清Cysc-C、UmAlb、Uβ2-MG水平均显著地高于正常人组（P ＜ 0.01）。肝硬化腹水组又明显高于无腹水组（P ＜0.01）。血清Cysc-C水平与UmAlb、Uβ2-MG水平呈显正相关（r=0.6011 、 0.5984， P ＜ 0.01）。结论 血清Cysc-C、UmAlb、Uβ2-MG均具有较好的反映肝硬化患者早期肾损伤的诊断价值。

Objective To explore the values of serum cystatin C (Cys-C), Urine Microalbuminand (UMAlb) and Urineβ2-Microglobin (β2-MG) in patients with liver cirrhosis. Methods The Serum Cys-C, umAlb (with immunoturbility assay) and Uβ2-MG (with ELISA) Levels were determined in 61 patients with liver cirrhosis (30 cases ascites the cirrhosis and 31 cases without ascites) and 35 healthy controls. Results The Serum Cys-C and UmAlb and β2-MG levels in patients were significantly higher than those in controls (P < 0.01). These markers in liver cirrhosis with ascites group were higher that that without ascites groups (P <0.01).The serum Cys-C levels were positively correlated with UmAlb and Uβ2-MG levels (r=0.6011，0.5984, P < 0.01). Conclusion The detection levels of serum Cys-C, UmALb and Uβ2-MG have important value in the early diagnosing renal function damage.