目的 检测健康体检人群中的血清胃蛋白酶原(pepsinogen, PG)含量，以明确其人群分布特征，同时观察分析PG在胃癌低发区表观健康人群中的分布特征。方法 利用化学发光法对苏州地区2993名健康体检人群进行血清PGⅠ、PGⅡ含量测定，并计算PGⅠ/PGⅡ比值(PGR)。采用乳胶法检测血清幽门螺旋杆菌(HP)抗体的阳性率。结果 该人群血清PGⅠ和PGR水平男性显著高于女性，而PG阳性率男女之间无差别；随着年龄的增长，PGⅠ、Ⅱ水平逐渐上升，而PGR 在60岁之前随年龄的增长呈下降趋势，60岁以后进入平台期；HP阳性组的PGⅠ、PGⅡ水平显著高于HP阴性组，但PGR显著低于HP阴性组。另，随着年龄的增长，PG阳性率逐渐增高，而HP阳性率变化不明显。结论 苏州地区体检人群的血清PG水平呈明显偏态分布，受性别、年龄、HP感染等因素的影响，且PG阳性率随年龄的增长而增长。

Objective To explore the serum level of pepsinogen (PG) in health check-up and their distribution as well as relative factors. Methods Chemiluminescence was used to detect the serum level of PGⅠ、PGⅡ and the ratio of PGⅠ/Ⅱ (PGR) for 2993 subjects of health check-up. The latex test was employed to detect the serum Helicobacter Pylori (HP) antibody positive rate. Results The results showed that the serum PGⅠand PGR level of males was significantly higher than that of females. There was no significantly difference in males and females for the positive rate of PG detection. The PGⅠ and PGⅡ level increased with age. While the PGR showed a downward trend until age of 60 and then maintained at plateau. For the HP-positive group, the serum levels of PGⅠ and PGⅡ were significantly higher than those of the HP-negative group, while the PGR was significantly lower. Besides, the PG-positive rate gradually increased with age, while the HP-positive rate did not change significantly. Conclusion The serum PG levels are significantly skewed from normal distribution in the residents of Suzhou county, and affected by age and gender, as well as associated with HP infection. The PG positive rate is increased with age.