目的 探讨血清基质金属蛋白酶-3(matrix metalloproteinases-3，MMP-3) 与类风湿关节炎(rheumatoid arthritis，RA)及其炎症反应的相关性。方法 用免疫比浊法(immunoturbidimetric assays) 检测146例RA 患者( RA 组) 及232例非RA人群( 对照组) 血清MMP-3 水平;对两组MMP-3结果进行ROC曲线分析;分析RA患者血清MMP-3与反映RA患者炎症活动程度临床指标的关系。结果 RA 组血清MMP-3 浓度为170.00±19.36 ng /mL，明显高于对照组的47.92±1.98 ng /mL,差异有统计学意义( P ＜0.001）。血清MMP-3诊断RA的ROC曲线下面积为0.731，取诊断界限值为71.65ng/mL时，敏感度为58.9%，特异度为88.79%。RA组患者血清MMP-3水平与其他RA诊断以及反应RA炎症反应的指标，如C反应蛋白（C-reaction protein, CRP）、前白蛋白（prealbumin， PA）、血沉（erythrocyte sedimentation rate，ESR）、血小板（platelet）以及白细胞计数（WBC）均具有显著相关性，P值均＜0.001。 结论 RA 患者血清MMP-3水平显著高于正常人，其水平与反映RA患者炎症活动程度临床指标CRP、PA、ESR、PLT以及WBC具有显著相关性。类风湿性关节炎患者血清MMP-3水平与类风湿性关节炎的炎症活动性有关。

Objective To investigate the relationship between serum matrix metalloproteinase-3 and rheumatoid arthritis. Methods The serum MMP-3 level in 146 patients with RA and 232 non RA patients were detected by immunoturbidimetry. The receiver operating Curve (ROC) analysis was carried out to get the cut-off value. The relationship between MMP-3 and other clinical biochemical indices were analyzed by multiple regressions. Results The serum MMP-3 concentration in RA group (170±19.36 ng /mL) was significantly higher than that of control group (47.92±1.98 ng /mL)（P＜0.001). The optimal diagnostic cut-off value for MMP-3 was 71.65 ng/mL. The sensitivity and specificity were 58.9% and 88.79% respectively at this cut-off value. The serum concentration of MMP-3 in RA patients was significantly correlated with inflammation and activity indices such as C-reaction protein, prealbumin, erythrocyte sedimentation rate, platelet, white blood cell count (P<0.001). Conclusion The serum MMP-3 levels in patients with rheumatoid arthritis is correlated to inflammatory activity.