目的 探讨脑胶质瘤患者脑组织中LMO-1和LMO-4基因表达水平的改变及其意义。方法 采用实时荧光定量聚合酶链反应(real-time PCR)检测45例脑胶质瘤手术患者脑组织及19例正常脑组织标本中LMO1和LMO4的表达水平，分析LMO1、LMO4与病理分级之间的关系。结果 脑胶质瘤患者脑组织中LMO1表达高于正常对照组（P<0.05）；LMO1在不同分级的胶质瘤中表达并不相同，在Ⅲ、Ⅳ级中的相对表达量显著高于Ⅰ、Ⅱ级（P<0.01）；LMO1表达水平与胶质瘤分级正相关，差异具有显著性意义（P<0.05）。在多形性胶质母细胞瘤患者脑组织中，LMO4的表达明显高于其它级别胶质瘤和正常对照组（P<0.05）。结论 脑胶质瘤患者肿瘤组织中LMO1和LMO4表达增高，可能参与了胶质瘤的发生、发展过程。

Objective To investigate the expression of LMO1 and LMO4 in human glioma and normal brain tissues and evaluate their clinical significance. Methods The levels of LMO1 and LMO4 in brain specimens collected from 45 patients with gliomas and 19 normal controls were measured by quantitative real-time PCR. The relationship between these expressions and pathological grade were also analyzed. Results LMO1 expression in brain specimens of glioma patients was statistically higher than that in the controls. Compared with that in low-grade gliomas, the levels of LMO1 in high-grade gliomas were significantly increased. There was a positive correlation between LMO1 expression level and the pathological grade of gliomas. LMO4 mRNA levels were higher in glioblastoma multiform than the well-differentiated glioma and normal brain tissues. Conclusion The expression of LMO1 and LMO4 are elevated in glioma patients. They may participate in the occurrence and development of glioma.