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临床研究

18F-FDG PET/CT盆部延迟显像在原发性膀胱癌诊断和局部分期中的临床价值

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  • 上海交通大学附属第一人民医院核医学科,上海 200080

收稿日期: 2014-06-30

  修回日期: 2014-09-03

  网络出版日期: 2014-11-06

The Clinical Value of 18F-FDG PET/CT Delayed Imaging of Pelvis for Detection and Locoregional Staging of Urinary Bladder Cancer

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  • Department of Nuclear Medicine, Shanghai First People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200080, China

Received date: 2014-06-30

  Revised date: 2014-09-03

  Online published: 2014-11-06

摘要

目的 观察18F-FDG PET/CT盆部延迟显像在原发性膀胱癌的诊断和局部分期中的价值。方法 27例疑似膀胱癌患者,术前均行增强CT及18F-FDG PET/CT常规加盆部延迟显像进行诊断和分期,以手术病理结果作为金标准,观察盆部延迟显像在原发性膀胱癌诊断和局部分期上的价值,并与增强CT作比较。结果 27例患者中,增强CT、盆部延迟显像诊断原发肿瘤的灵敏度分别为77.27%、90.90%;特异度分别为60.00%、40.00%;准确度分别为74.07%、81.48%;盆部延迟显像和增强CT诊断准确度比较无统计学差异(P=0.263)。12例患者接受了膀胱癌根治术,其中10例有盆腔淋巴结或邻近组织转移,增强CT、盆部延迟显像局部分期准确度分别为33.33%、91.67%,盆部延迟显像优于增强CT(P=0.018)。结论 18F-FDG PET/CT盆部延迟显像在原发性膀胱癌的诊断上与增强CT具有同等价值,局部分期准确度优于增强CT,具有更高的临床价值。

本文引用格式

汪太松,赵晋华,宋建华,刘长存 . 18F-FDG PET/CT盆部延迟显像在原发性膀胱癌诊断和局部分期中的临床价值[J]. 标记免疫分析与临床, 2014 , 21(5) : 543 . DOI: 10.11748/bjmy.issn.1006-1703.2014.05.015

Abstract

Objective To evaluate the potential ability of 18F-FDG PET/CT delayed imaging of pelvis for detection and locoregional staging of urinary bladder tumors. Methods Twenty-seven patients suspected with primary carcinoma of the urinary bladder were evaluated prospectively for diagnosis and staging. The patients underwent conventional contrast-enhanced computed tomography (CECT) of the pelvis and whole-body 18F-FDG PET/CT. In addition, delayed pelvic PET/CT images were obtained after oral hydration. Results of CECT and 18F-FDG PET/CT were compared considering histopathology as a reference standard to evaluate the value of delayed pelvic PET/CT images in detection and locoregional staging of urinary bladder tumors. Results Of the 27 patients, the sensitivity of CECT and delayed pelvic PET/CT was 77.27% and 90.90% respectively; the specificity was 60.00% and 40.00% respectively; and the accuracy rate was 74.07% and 81.48% respectively. The accuracy rate of delayed pelvic PET/CT imaging and CECT had no statistical difference (P=0.263). Twelve patients underwent radical cystectomy, ten had locoregional metastases. The accuracy rate in locoregional staging of CECT and delayed PET/CT was 33.33% and 91.67%, respectively. Delayed PET/CT was superior to CECT (P=0.018). Conclusion 18F-FDG PET/CT delayed imaging of pelvis has a good sensitivity and accuracy rate in detection of urinary bladder cancer as good as CECT, and might be more better in locoregional staging of urinary bladder cancer.
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