目的 探讨定量检测血清肿瘤标志物CA125在原发性肝细胞肝癌患者早期腹水中临床意义，评价CA125作为肝癌腹水诊断的实验室指标价值。方法 采用回顾性分析研究，对云南省肿瘤医院介入科2013年7月到2014年1月共计111例原发性肝细胞肝癌患者，对照组为我院健康体检者23例，采用全自动化学发光检测血清CA125，并同时采用腹部CT及B超诊断患者腹水。对32例肝癌患者进行2次以上跟踪检测血清CA125。对血清CA125与肝储备功能child-pugh分级进行比较两者的相关性。数据统计处理采用spss17.0版统计分析软件。各组间CA125值差异性比较采用Mann-Whitney U检验；阳性率用χ2检验比较；各组间CA125值与child分级的相关性用Spearman等级相关性分析。结果 肝癌腹水组CA125 结果为287.33U/mL ，肝癌无腹水组CA125结果37.15 U/mL，健康对照组为15.96 U/mL，各组之间CA125 水平比较P<0.01，提示有显著性差异；肝癌腹水组CA125阳性率为88.6%，肝癌无腹水CA125阳性率37.31%，健康对照组阳性率7.69%，各组之间CA125阳性率比较χ2=49.685，P<0.01,有显著性差异；32例跟踪检查患者中，无腹水稳定组有12例，CA125为29.56 U/mL；无腹水进展组有15例，CA125为168.35 U/mL；腹水组有5例，CA125结果为187.00 U/mL，进展组血清CA125与稳定组比较P<0.01,差异具有统计学意义，进展组与腹水组比较P<0.05,差异具有统计学意义；CA125与child-pugh-分级相关性研究，其中child-A 有83例， CA125结果为57.17 U/mL ；child-B有18例，CA125结果为268.14 U/mL；child-C有10例， CA125为581.05 U/mL，血清CA125与child-pugh分级的相关性系数r=0.665,P<0.01,提示2者之间有显著性相关。结论 血清CA125可作为诊断肝癌并发腹水的实验室检查方法；血清CA125与child-pugh分级密切相关。

Objective To explore the clinical value of serum CA125 in early ascites of primary hepatic carcinoma. Methods The serum CA125 levels in 111 patients with primary hepatic carcinoma and 23 health controls were determined. The CT scan and ultrasound examinations were used to detect the ascites in patients. The results were analyzed statistically. Results The CA125 level in primary hepatic carcinoma with ascites was obviously higher than that of non-ascites patients and controls (P<0.01). The serum CA 125 levels in stable non-ascites patients, developing of the patient and ascites patients were 29.56 U/mL, 168.35 U/mL and 187.00 U/mL respectively. The serum CA125 levels was correlated with degree of Child-Pugh (r=0.665, P<0.01). Conclusion The serum CA125 could be used to a useful method to diagnosis detection of primary hepatic carcinoma with ascites.