目的 探讨乳腺癌患者血清IL-6、IL-1β、TNF-ɑ 的变化及其临床意义。方法 应用放射免疫法和免疫比浊法检测66例乳腺癌患者、22例乳腺良性增生患者、62名健康对照者空腹血清 IL-6、 IL-1β、TNF-ɑ 水平。用ROC曲线方法确定各指标的最佳诊断临界值，用Logistic回归分析方法进行三种指标联合分析。结果 乳腺癌组血清三种指标水平均高于乳腺良性增生组和健康对照组(P＜0.05)。单独用其中一种指标鉴别诊断的敏感性和特异性均不超过83%，若用Logistic回归分析联合“IL-6+IL-1β+TNF-ɑ”鉴别诊断乳腺癌和乳腺良性增生的敏感度可以达到96.7%，但特异度仅71.4%。结论 血清IL-6、IL-1β、TNF-ɑ可作为乳腺癌鉴别诊断的辅助指标。

Objective To investigate the clinical significance of serum IL-6, IL-1β and TNF-ɑ in patients with breast cancer. Methods Serum levels of IL-6, IL-1β and TNF-ɑ were detected in 66 patients with breast cancer, 22 patients with benign breast hyperplasia and 62 health controls. The logistic regression model and the ROC curves were used to evaluate the diagnostic value of IL-6, IL-1β and TNF-ɑ for breast cancer. Results The serum levels of IL-6, IL-1β and TNF-ɑ in patients with breast cancer were significantly higher than that of other groups (P＜0.05). The diagnostic sensitivity and specificity with any single index was lower than 83%. By logistic regression analysis of “IL-6+IL-1β+TNF-ɑ”, the sensitivity of detection reached 96.7%, but the specificity was still only 71.4%. Conclusion The Serum IL-6, IL-1β and TNF-ɑ can be used as auxiliary index in the differential diagnosis of breast cancer.