目的 探讨彩色多普勒超声（CDFI）引导下125I粒子组织间植入治疗转移性浅表肿瘤的疗效。方法 回顾性分析156例确诊为恶性转移性浅表肿瘤患者进行125I粒子治疗结果，利用薄层CT扫描图像进行计算机三维治疗计划系统（TPS）术前计划、术中调整、术后验证粒子分布及数量。局部浸润麻醉后，CDFI引导下植入125I粒子。结果 术后3个月，16.7％(26/156)患者肿瘤完全缓解，51.3％(80/156)患者肿瘤部分缓解，21.1％(33/156)肿瘤稳定，10.9％(17/156)肿瘤进展．总有效率(CR+PR)为68％。术后6个月，18.6％(29/156)患者肿瘤完全缓解，53.2％(83/156)患者肿瘤部分缓解，22.4％(35/156)肿瘤稳定，5.8％(9/156)肿瘤进展．总有效率(CR+PR)为71.8％。无严重皮肤反应、骨髓抑制及其它并发症发生。结论 CDFI引导下125I粒子植入治疗转移性浅表肿瘤具有方法简单、定位准确、疗效确切、无严重并发症等优点，是一种安全的微创治疗手段。

Objective To analyze the clinical effect of CDFI-guided 125I seed implantation in the treatment of metastatic superficial tumor. Methods A retrospective analysis of 156 patients with metastatic superficial tumors treated with CDFI-guided 125I seed implantation was carried out. Three-dimensional computerized reconstruction and CT scanning with thin slice were used to make preoperative plan, operative adjustment and to verify the distribution and numbers of seeds after operation. The 125I seed were implanted under CDFI-guided after local infiltration anesthesia. Results Three month after operation, The tumors in 16.7％ of patients (26/156) were complete remission (CR), 51.3％ patients (80/156) were partial remission (PR), 21.1% patients (33/156) had no change (NC), 10.9％ patients (17/156) had progress disease (PD). The total effect rate was 68％ (CR+PR). Six month after operation, The tumors in 18.6％ of patients (29/156) were complete remission (CR), 53.2％ patients (83/156) were partial remission (PR), 22.4% patients (35/156) had no change (NC), 5.8％ patients (9/156) had progress disease (PD). The total effect rate was 71.8％ (CR+PR). There were no serious skin reactions, bone marrow suppression and other complications in all patients. Conclusion Brachytherapy with 125I seeds implantation guided with CDFI is a safe，minimally invasive and effective treatment method for metastatic superficial tumor.