近年来，颅内感染一直是神经外科术后常见的并发症之一，我国颅内感染的发生率为2.6%。颅内感染可引发严重的全身性并发症以及神经系统后遗症，具有较高的病死率和致残率，延长了住院时间，降低了手术效果。颅内感染包括细菌性脑膜炎和无菌性脑膜炎，鉴于临床上对于两者鉴别诊断的实验室参考指标有限，影响因素过多等原因，人们力求寻找更可靠的辅助诊断细菌性脑膜炎的指标，为临床更有效地使用抗生素提供更多参考，因此本文将对脑脊液降钙素原（PCT）、C反应蛋白（CRP）、乳酸（LA）、尿酸（UA）、脑脊液胆碱酯酶（CHE）、白细胞酯酶(LET)和细胞因子等对颅内感染诊断的价值进行综述。

In recent years，intracranial infection has been one of the common complications of neurosurgery. The incidence of intracranial infection is 2.6% in our country. It can cause serious systemic complications and neurological sequelae, leading to high mortality and morbidity, prolong the length of hospital stay and compromise the operation effect. Intracranial infection includes aseptic meningitis and bacterial meningitis. Given the limitation of clinical laboratory reference index for differentiation of aseptic meningitis and bacterial meningitis, we aim to find more reliable auxiliary diagnosis index of bacterial meningitis and provide more references for clinical more effective use of antibiotics, this article mainly reviews the procalcitonin (PCT) and c-reactive protein (CRP), lactic acid (LA), uric acid (UA), cerebrospinal fluid, cholinesterase (CHE), leukocyte esterase (LET) and cytokines in the cerebrospinal fluid on the value of diagnosis of intracranial infection.