目的 探讨北方地区人群血清乙型肝炎病毒（HBV）标志物的模式分布情况。 方法 对本院16553例术前检查患者采用化学发光免疫分析法(CLIA)检测血清HBV标志物。 结果 未感染过HBV患者5584例，占33.7%；既往或现症感染HBV患者10969例，占66.3%；其中，HBV表面抗原（HBsAg）携带者1431例，占8.6%。所有既往或现症感染HBV患者血清HBV标志物常见模式7种，占前三位的是： HBsAb单独阳性3983例，占24.1%；HBsAb、HBeAb、HBcAb均为阳性2492例，占15.1%；HBsAb和HBcAb阳性2085例，占12.6%；少见模式13种共323例，占2.0%。在所有HBsAb阳性(≥10mIU/mL)患者中，38.4%患者HBsAb水平≤100mIU/mL，仅31.5%患者HBsAb水平≥500mIU/mL，具有有效的保护作用。 结论 北方地区HBV感染率稍高于全国平均水平（7.18%）；且HBsAb阳性患者中，三分之一低于100mIU/mL，需进一步强化免疫，降低HBV感染率。

Objective To analysis serological infection modules of hepatitis B virus (HBV) in north China. Methods The serum HBV markers in 16553 patients were quantitatively detected with Architect chemiluminescence immunoassay (CLIA). Results 5584 patients were never infected by HBV, composed by 33.7%. 1431 patients were HBsAg carriers, composed by 8.6%. 7 kinds of serological modules were found in the previous or current HBV infenction patients. The first, second, third were: HBsAb alone positive (3983 cases, 24.1%), HBsAb and HBeAb and HBcAb positive (2492 cases, 15.1%), HBsAb and HBcAb positive (2085 cases, 12.6%), respectively. There were 323 cases of rare modules, composed by 2.0%. Among the HBsAb positive (≥10mIU/mL) patients, there were 38.4% in which HBsAb level was lower than 100mIU/mL， and only 31.5% patients over 500mIU/mL. Conclusion The positive rate of HBV was higher in north China than that of other areas (7.18%). In the HBsAb positive patients, there were almost one third in which HBsAb level was lower than 100mIU/mL, so action should be taken to protect from HBV infection.