目的 通过动态监测肾移植术后肾功能恢复稳定组（A组）、肾功能恢复不良组（B组）受者不同时间尿中指标的水平，探讨各指标动态变化的临床价值。方法 应用日立7600全自动生化分析仪对受者术后1 d、3 d、5 d、7 d、2w、3w尿中的指标进行动态监测。结果 1）从表中可见，两组术后血清胱抑素C(CYSC) 水平在1～５d时差异无统计学意义（P＞0.05），A组水平呈持续下降趋势；B组在3 d后CYSC水平出现持续反弹，2w、3 w时已超过１d，约为A组的2.5倍（P<0.01）；2）N-乙酰-β- D氨基葡萄糖苷酶（NAG) 1～７d时A组水平略高于B组（P＞0.0５），2w、3 w B组水平显著高于Ａ组（P<0.05）；3）尿CYSC水平在1～3d时Ａ组略高于B组（P<0.05），5～7d时两组差异无统计学意义（P＞0.0５），2～3w时B组约为A组的3倍（P<0.01）。4）A组1～7 d 时视黄醇结合蛋白（RBP）水平高于B组（P<0.05或P<0.01，5 d除外），B组在2w、3w时水平显著高于A组( P<0.01）。5）1～3 d 时B组的尿γ-转肽酶（GGT）水平显著高于A组（P<0.01），至2w、3w时B组的GGT水平为A组的8～10倍（P<0.01）。结论 本研究中Ａ组术后早期的肾小管功能受损较Ｂ组略重，但3w内肾小管、肾小球滤过功能均恢复良好；Ｂ组2～3w时肾小管、肾小球滤过功能严重受损。

Objective To explore the clinical significance of monitoring parameters in urine of the recipients after renal transplantation. Methods The patients after renal transplantation were divided into renal function stable recovery group (A) and poor renal function recovery group (B). Hitachi 7600 blood biochemical analyzer was used to measure all parameters in urine of patients after renal transplantation at different times. Results There was no significantly difference on the serum level of CYSC between two groups from 1-5 days（P>0.05）. The serum level of CYSC in group A was decreased. The serum levels of CYSC in group B were to rebound after 3 days, and the levels of CYSC at week 2 and week 3 exceed that at the first day, and it was about 2.5 times as the level in group A（P<0.01）. The levels of NAG in group A at day 1 to day 7 were a little bit higher than that in group B（P＞0.05），but they were much higher than that in group A at week 2 and week 3（P<0.05）. The levels of CYSC in urine of group A were higher than that in group B at day 1-3（P<0.05）, but the levels of CYSC in urine of group B were about 3 times as group A at week 2-3（P<0.01）. The levels of RBP in group A were higher than that in group B（P<0.05）,but the levels of group B at week 2-3 were obviously higher than that in group A ( P<0.01）. The levels of GGT in urine in group B were obviously higher than that in group A at day 1-3 ( P<0.01）, but the levels of GGT in urine of group B at week 2-3 were about 8-10 times as group A（P<0.01）. Conclusion The function of nephric tubule in group A damaged much more serious than that in group B, but the functions of nephric tubule and renal glomerulus recovered well within 3weeks. Inversely the functions of nephric tubule and renal glomerulus in group B were damaged seriously.