目的 探讨慢性丙型肝炎患者血清LPO、SOD和IGF-Ⅰ水平的变化及分析研究。方法 应用放射免疫分析法，对66例慢性丙型肝炎患者进行血清过氧化脂质、超氧化物歧化酶和胰岛素样生长因子-Ⅰ含量的测定，并与同期收集的72名正常健康人作比较。结果 慢性丙型肝炎患者血清LPO、IGF-Ⅰ水平显著高于正常人组﹙P<0.01﹚，而血清SOD水平则显著低于正常人组﹙P<0.01﹚。经综合治疗两个月后血清LPO、SOD和IGF-Ⅰ水平与正常人组比较差异无统计学意义（P>0.05）。结论 检测慢性丙型肝炎患者血清LPO、SOD和IGF-Ⅰ水平的变化，对分析研究慢性丙型肝炎的发病机理、疾病发生发展有重要的临床价值。

Objective To explore the changes of serum levels of LPO, SOD and IGF-Ⅰin patients with chronic hepatitis C. Methods The serum levels of LPO, SOD and IGF-Ⅰin 66 cases of patients with chronic hepatitis C and 72 healthy controls were detected by RIA. Results The serum levels of LPO and IGF-Ⅰin chronic hepatitis C patients were significantly higher than that of normal controls (P < 0.01), while the serum SOD levels were significantly lower than normal controls (P < 0.01). The serum LPO, SOD and IGF-levels in patients after 2 months comprehensive treatment had no significant difference compared with normal group (P > 0.05). Conclusion The detection of changes of serum LPO, SOD and IGF-I levels has clinical value in the study of the mechanism, occurrence and development of chronic hepatitis C.