目的 研究降钙素原在结核病诊断中的应用效果，为其临床应用和相关研究提供科学依据。方法 将2011年6月至2013年期间，在本院接受治疗的154例结核病患者设为治疗组，对其临床资料进行回顾性分析，同时选取30名健康人作为对照组， ELISA方法分析两组血清降钙素原浓度，并评估降钙素原应用于结核病诊断的价值。结果 经研究证实，活动性肺结核患者血清降钙素原浓度明显高于对照组和其他结核病组，差异具有统计学意义，（P＜0.05），且肺外结核患者组高于对照组和非活动性肺结核组，组间差异具有统计学意义，（P＜0.05）。经分析发现，采用降钙素原诊断活动性肺结核的临界数值为0.15ng/mL，其用于诊断的特异性和敏感性分别为81.2%、76.9%。经临床对症治疗后，活动性肺结核患者血清降钙素原含量显著下降。结论 降钙素原可用于活动性肺结核的诊断。

Objective To explore the clinical value of procalcitonin in the diagnosis of tuberculosis (TB) patients. Methods The serum procalcitonin levels in 154 cases of treated tuberculosis patients and 30 healthy controls were measured by ELSA. Results The serum procalcitonin levels in active pulmonary tuberculosis patients were higher than that of the control group and the other tuberculosis group (P < 0.05). The serum procalcitonin levels in extra pulmonary tuberculosis patients group were higher than that of in control group and non-active pulmonary tuberculosis group (P< 0.05). The critical value of procalcitoninin diagnosis of active pulmonary tuberculosis was 0.15ng/mL. The diagnostic specificity and sensitivity were 81.2%, 76.9% respectively. The serum procalcitonin levels in patients with active pulmonary tuberculosis decreased significantly after treatment. Conclusion The serum procalcitonin levels could be used in the diagnosis of active pulmonary tuberculosis.