目的 研究血清脂蛋白（a）[ Lp(a)]水平及人载脂蛋白a基因SNP rs3798220（LPA SNP rs3798220）与冠心病的相关性。方法 以200例冠脉造影证实为冠心病的患者为冠心病组，以200名健康者为对照组，采用高分辨熔解曲线分析方法（HRM）分析LPA SNP rs3798220与冠心病的相关性，并测定Lp(a)水平。结果 冠心病组T/C+C/C型频率、C等位基因频率均高于对照组（P<0.05）。Logistic回归分析发现，LPA SNP rs3798220 T/C+C/C型与冠心病正相关（OR：2.878，95.0% CI：1.306~6.339，P<0.05），Lp(a)水平与冠心病的发病呈正相关（OR：1.068，95.0% CI：1.041-1.095，P<0.05）。结论 载脂蛋白a基因SNP rs3798220 T/C+C/C型可能是冠心病的易感基因型，血清Lp(a)水平可能是冠心病的一个危险因素。

Objective To investigate the relationships among serum lipoprotein (a) levels and apolipoprotein (a) gene SNP rs3798220 T/C polymorphism and coronary heart disease (CHD). Methods The CHD patients diagnosed by the coronary angiography were selected as CHD subjects (200 cases), and 200 healthy adults served as normal control subjects. The High Resolution Meiting (HRM) was performed to identity the distribution pattern of apolipoprotein (a) gene SNP rs3798220 in all subjects. The levels of serum lipoprotein (a) were measured. Results The frequency of T/C+C/C genotype and C allele in CHD patients were significantly higher than those in control subjects (P<0.05). Logistic regression analysis revealed that LPA SNP rs3798220 T/C+C/C genotype had a strong positive association with CHD (OR：2.878，95.0% CI：1.306~6.339，P<0.05). The serum lipoprotein (a) was positive associated with CHD (OR：1.068，95.0% CI：1.041~1.095，P<0.05). Conclusion The T/C+C/C genotype might be a possible risk factor for CHD and the serum lipoprotein (a) levels may have an association with the CHD .