目的 探讨肝硬化患者血清IGF-Ⅰ和IL-6、IL-8水平的变化及临床意义。方法 应用放射免疫分析法，对33例肝硬化患者进行血清IL-6、IL-8和IGF-1含量的测定，并与同期收集的32名正常健康人作比较。结果 肝硬化患者血清IGF-Ⅰ水平非常显著地低于正常人组﹙P<0.01﹚，而血清IL-6、IL-8水平非常显著地高于正常人组﹙P<0.01﹚。且血清IGF-Ⅰ水平和IL-6、IL-8水平呈显著负相关﹙r=-0.4025、-0.5236，P<0.01﹚。结论 检测肝硬化患者血清IGF-Ⅰ和IL-6、IL-8水平的变化，对该病的诊断、指导肝硬化的治疗及观察疗效均有重要的临床价值。

Objective To explore the changes and clinical significance of serum IGF-I, IL–6 and IL-8 levels in patients with cirrhosis. Method The serum levels of IGF-I, IL–6 and IL-8 levels in 33 cases of patients with cirrhosis and 32 normal healthy people were detected by RIA. Results The serum IGF-I level in patients with cirrhosis were significantly lower than normal controls (P < 0.01), while the serum level of IL–6 and IL-8 levels were significantly higher than in normal group (P < 0.01). The Serum IGF-I level was negatively correlated with the level IL–6 and IL-8 ( P < 0.01). Conclusion It might be very important to detect the changes of serum IGF-I, IL–6 and IL-8 levels in the diagnosis, guiding the treatment and monitoring the curative effect in patients with cirrhosis.