目的 探讨血清CYFRA21-1、CA72-4、CA125对食管癌的诊断价值。方法 采用放射免疫分析法检测79名正常健康对照者、350例食管癌患者血清CA125、CA72-4和CYFRA21-1的水平。结果 对食管癌患者组，CYFRA21-1的界值为1.8ng/mL时，其敏感性、特异性等优于其他界值。三种肿瘤标志物CYFRA21-1、CA72-4和CA125阳性检出率分别为49.16%、30.89%、13.81%。多种肿瘤标志物联合检测中，CYFRA21-1和CA72-4联检，阳性检出率为65.00%，CYFRA21-1和CA125联检，阳性检出率为47.56%，CA125和CA72-4联检，阳性检出率为31.00%。结论 食管癌患者组CYFRA21-1的界值为1.8ng/mL时，三种肿瘤标志物中CYFRA21-1对食管癌患者的阳性率优于CA125及CA72-4；CYFRA21-1和CA72-4联合检测优于其他两种肿瘤标志物联合检测。

Objective To investigate the diagnosis value of the serum levels of CA125, CA72-4 and CYFRA21-1 in patients with esophageal patients. Methods The serum levels of CA125, CA72-4 and CYFRA21-1 in 320 esophageal patients and 79 healthy controls were measured by radioimmunoassay. Results When the cut-off values of serum CYFRA21-1 was 1.8 ng/ml, the clinical significant is better than other cut-off. The levels of CYFRA21-1, CA-72-4 and CA125 in esophageal patients were significant higher than that of healthy controls (P＜0.01). The positive rate of CYFRA21-1, CA72-4 and CA125 in esophageal patients were 49.16%，30.89% and13.81% respectively. The positive rate of combination of CYFRA21-1 and CA72-4 was 65%, and that of combination of CYFRA21-1 and CA125 was 47.56%, that of combination of CA125 and CA72-4 was 31.00%. Conclusions The combined detection of CYFRA21-1 and CA72-4 are super than other two tumor markers.