摘要：目的 探讨血清胱抑素C(CysC)在早期糖尿病肾病（DN）患者血液中的变化及其诊断价值。方法 对120例2型糖尿病(T2DM)患者根据尿微量白蛋白排泄率（UAER）分为两组：T2DM无蛋白尿组（UAER<30mg/24h）,60例；T2DM微量蛋白尿组（UAER30～300mg/24h），60例；用免疫比浊法检测2型糖尿病肾病患者和健康体检人群的血清CysC，速率法测定尿素氮（BUN），酶法测定血肌酐（Scr）,并对检测结果进行统计分析。结果 60例T2DM 尿微量白蛋白患者CysC、BUN、Scr的异常结果检出率分别为80.0%、10.0%、18.3%，CysC的异常结果检出率明显高于BUN、Scr。结论 血清中CysC的浓度可作为2型糖尿病肾病早期诊断指标，且对了解肾脏损伤程度也有较大的临床意义。

Abstract: Objective To investigate the changes and clinical value of serum cystain C (CysC) in patients with early diabetic nephropathy (DN). Methods According to the urine trace albumin excretion rate (UAER), 120 Type 2 diabetic (T2DM) patients were divided into DM without albuminuria （UAER<30mg/24h, 60 cases) group and DM with microalbuminuria （UAER30-300mg/24h, 60 cases) group. The serum CysC, BUN and serum creatinine in T2DM and health controls were detected by using immune turbidimetric, Immunization rate and enzymatic determination respectively. Results The abnormal detection results of serum CysC, BUN and Scr in 60 T2DM patients with microalbuminuria were 80.0%, 10.0% and 18.3% separately. The abnormal results rate of CysC was apparently higher than that of BUN and Scr. Conclusion Serum CysC concentrations could be used as the early diagnosis index in T2DN, and also will share great clinical significance in detecting the degree of kidney damage.