目的 观察自拟中药清肝消瘿方改善甲亢131I治疗早期症状的疗效。方法 对进行131I治疗的487例患者随机双盲分为：治疗组251例，服131I后对症治疗加中药清肝消瘿方；对照组236例，服131I后仅对症治疗。在患者服131I后14天、21天和28天，分别观察手抖、失眠、多汗、心率及大便次数并记录，用SPSS18.0统计软件。手抖、失眠、多汗用卡方检验，心率、大便次数用t检验。结果 在治疗后3个时间点观测，治疗组与对照组比较，手抖、失眠、多汗症状均明显改善（P＜0.05）；心率明显减少（P＜0.05）；大便次数明显减少（P＜0.01）。结论 甲亢131I治疗早期，中西医结合治疗对迅速改善、缓解甲亢患者症状有明显效果，有效提高了患者的诊疗舒适度。

Objective To observe the therapeutic effect of Chinese medicine Formula (Qing gan xiao ying) on early symptoms of hyperthyroidism patients after 131I treatment. Methods 487 hyperthyroidism patients with 131I treatment were randomly divide treatment group (with Chinese medicine, n=251) and control group (no Chinese medicine, n=236). After 131I treatment, the patients in treatment group received symptomatic treatment plus Chinese medicine Qing gan xiao ying, while the patients in control group only received symptomatic treatment. After 14, 21 and 28 days of 131I treatment, the patients were observed on tremor, insomnia, sweating, heart rate and the frequency of defecation. Results The relieves of tremor, sweating and insomnia symptoms in patients with Chinese medicine treatment group were significantly higher than that of control group (P < 0.05). The average heart rate and stool frequency in treatment group were lower than that of control group (P < 0.05). Conclusion In early stage of 131I treatment in patients with hyperthyroidism, there have apparent effect for rapidly ameliorating and relieving the symptom of hyperthyroidism patients by combined Chinese and Western medicine treatment.