目的 分析不同甲状腺功能状态对孕妇血脂代谢的动态影响。方法 筛选甲状腺功能正常孕妇30名、亚甲减孕妇19名及亚甲亢孕妇8名。测定孕9~12、 14~17、 23~26和37~40周四个妊娠时段的空腹血清总胆固醇（CHOL）和甘油三酯（TRIG）含量并统计分析。结果 统计分析结果表明，亚甲亢组与正常孕妇组、亚甲亢组与亚甲减组，血清CHOL含量的差异均有统计学意义（P<0.05），正常孕妇组与亚甲减组血清CHOL含量的差异无统计学意义（P>0.05）。三组孕妇血清TRIG含量的差异均无统计学意义（p>0.05）。结论 妊娠期孕妇血清CHOL和TRIG含量总体呈上升趋势。亚甲亢组血清CHOL含量较正常孕妇组低，亚甲减组（药物治疗）孕妇血清CHOL含量与正常孕妇组无差别。此两种甲状腺功能异常对孕妇血清TRIG代谢均无影响。

Objective To study the dynamic change of lipid metabolism in different thyroid function status during pregnancy. Methods This study recruited thirty cases of euthyroid, nineteen cases of subclinical hypothyroid and eight cases of subclinical hyperthyroid pregnancy. The concentrations of fasting serum total cholesterol（CHOL）and triglyceride（TRIG）were detected and analyzed at 9-12, 14-17, 23-26, and 37-40 gestational weeks. Results The statistical analysis showed that there were significant differences of maternal serum CHOL between subclinical hyperthyroid and euthyroid pregnancy, subclinical hyperthyroid and subclinical hypothyroid pregnancy (P<0.05). There was no significant difference between euthyroid and subclinical hypothyroid pregnancy (P >0.05). There was no significant difference of maternal serum TRIG among the three groups (P >0.05). Conclusion The concentrations of maternal CHOL and TRIG increased during pregnancy. The serum CHOL of subclinical hyperthyroid pregnancy was lower than that of euthyroid pregnancy. Concentrations of maternal serum CHOL was similar between euthyroid and subclinical hypothyroid pregnancy after treatment with drug. Different thyroid function status had no obvious effect on the metabolism of maternal TRIG.