目的 对131I治疗结节性甲状腺肿并甲亢的效果进行临床分析。 方法 对确诊为结节性甲状腺肿并甲亢的260例患者采用131I治疗，结合结节情况、甲状腺吸碘率、甲状腺重量及甲状腺B超检查等确定131I剂量，并随访3～60个月。2~6个月后复查甲功，根据甲功情况给予左甲状腺素钠片25~150g/日，抑制TSH增高及治疗甲减。结果 260例患者131I甲亢治愈率为65.39%（170/260），甲亢好转率为20.00%（52/260），甲减发生率14.61%(38/260)，总体有效率100%（含甲减）；131I治疗后结节消除占78.85%（205/260），结节缩小占15.39%（40/260），结节治疗无效占5.77%（15/260）。结节直径越小的疗效越好（P＜0.05）。结论 131I治疗结节性甲状腺肿并甲亢疗效较好，适合有手术禁忌证或拒绝手术的患者。

Objective To study the treatment effect of 131I in nodular goiter and hyperthyroidism. Methods The thyroid nodules numbers and iodine absorption rate in 260 patients confirmed with nodular goiter and hyperthyroidism were determined, and the patients were treated with 131I and followed-up for 3 to 60 months. The patients were then given levothyroxine sodium 25 ~ 150 g/day based on their health situation to inhibit the increase TSH and hypothyroidism. Results The curative rate of hyperthyroidism with 131 I treatment was 65.39%, and partial rate was 20.0%, and hypothyroidism rate was 14.61%. After 131 I treatment, 78.85% of nodules was eliminated, nodular narrow accounted for 15.39% and nodular invalid accounted for 5.77%. The curative effect of smaller diameter nodal was better than larger ones (P < 0.05). Conclusion 131I therapy is suitable method for nodular goiter and hyperthyroidism treatment with good curative effect, especially for patients with surgery contraindication.