目的 为探讨β-HCG检测在拟行131I治疗育龄期女性甲亢患者中的临床价值。方法 对拟行131I治疗的420例育龄期女性甲亢患者的临床资料及血清β-HCG、FT3、FT4、TSH结果进行回顾性分析。结果 18～35岁年龄段各组的女性甲亢患者β-HCG阳性率比较，差异无统计学意义（P>0.05）；36～40岁年龄段组与18～35岁年龄段组女性甲亢患者β-HCG阳性率比较，差异有统计学意义（P<0.01）；月经减少、紊乱或闭经组β-HCG水平明显高于月经正常组 (P<0.01)；月经正常组与月经减少、紊乱或闭经组的FT3、FT4、TSH水平比较，差异无统计学意义 (P> 0.05)。结论 月经减少、紊乱或闭经的育龄期甲亢患者更可能合并妊娠，育龄期女性甲亢患者在拟行131I治疗前应常规检测血清β-HCG，防止早孕的漏诊，避免误治。

Objective To explore the clinical value of the serum β-HCG detection in 131I treatment of patients of child-bearing age with hyperthyroidism. Methods The clinical data and serum β-HCG, FT3, FT4, TSH and TRAb levels of 420 female patients of child-bearing age with hyperthyroidism were retrospectively analyzed. Results The results showed that the incidence pregnancy with hyperthyroidism was 5.7%. There was no significantly difference on incidence of pregnancy among the women patients aged 18 ~ 35 with hyperthyroidism. There was a significant difference in the incidence of pregnancy between the group aged 36~40 and the group aged 18~35 of female patients with hyperthyroidism. The serum β-HCG levels in menstrual reduction, menstrual disorder or amenorrhea group were significantly higher than normal menstruation group (P <0.01). There were significant differences in thyroid hormone levels of FT3, FT4, TSH and TRAb between normal menstruation group and reduced menstruation, disordered menstruation or amenorrhea group. The research shows that the patients of child-bearing age with hyperthyroidism were more likely in pregnancy when they were in menstrual reduction, menstrual disorder or amenorrhea period. Conclusion Patients of child-bearing age with hyperthyroidism should carry out the routine detection of serum β -HCG before they have 131I treatment, in order to prevent missed diagnosis of early pregnancy.