目的 探讨分化型甲状腺癌(DTC)甲状腺清除术后血清甲状腺球蛋白(Tg)联合131I-全身显像(131I-WBS)，为判定甲状腺癌的复发及转移提供参考依据。方法 56例DTC患者，甲状腺全切或次全切术后4～6周，均行131I清除残余甲状腺治疗，3～6个月后重复治疗，治疗前停用甲状腺激素3～6周，同时忌碘饮食，治疗中检测血清Tg，同时口服碘化钠(131I)治疗剂量3.70～7.40 GBq后5～7天行131I - WBS。 结果 在首次清除残留甲状腺组织治疗时，显像发现淋巴结、肺及骨转移8例，其余转移灶于3～6个月后二次治疗时发现，有11例患者(19.6％)Tg测定在正常范围，而131I-WBS出现转移灶；有7例患者(12.5％)Tg测定异常，而131I-WBS正常。结论 Tg测定和131I-WBS可作为诊断DTC术后复发及转移的重要指标，二者应联合应用、互相补充，具有重要的临床价值。

Objective To investigate explore clinical value of combined detection of serum Tg with 131I-body scintigraphy (131I-WBS) in patients with differentiated thyroid carcinoma (DTC). Methods 56 cases of DTC patients who total thyroidectomy or subtotal after 4 to 6 weeks were underwent removal of residual thyroid 131I therapy and repeated treatment for 3 to 6 months. The serum Tg levels were detected and 131I-WBS were performed. Results After first time removing residual thyroid tissue therapy, the 131I-WBS imaging found the lymphnodes, lung and bone metastases in 8 cases, the other metastases lesions were found in the rest of the secondary treatment for 3 to 6 months. The serum Tg levels in 11 patients (19.6%) were in normal range, while the 131I-WBS imaging appeared to have metastases lesions. 7 patients (12.5%) with abnormal Tg levels showed normal 131I-WBS imaging. Conclusion The serum Tg and 131I-WBS can be used as important indicators in diagnosis of DTC recurrence and metastasis. The combined detection of two methods should have important clinical value to improve the diagnostic accuracy.