摘要：目的  通过测定妊娠高血压综合征患者血清叶酸和维生素B₁₂水平，探讨孕妇叶酸、维生素B₁₂水平与妊娠高血压发生的关系。方法  选择妊娠高血压孕妇25例，正常孕妇30名，正常非妊娠体检女性35名，采用化学发光免疫分析技术（CLIA）测定每组叶酸和维生素B₁₂水平，比较各组之间的差异。结果  正常孕妇组叶酸和维生素B₁₂水平与正常体检女性组无明显差异，妊高症患者组叶酸及维生素B₁₂水平均明显低于其他两组（P<0.05）。结论  孕妇血清叶酸和维生素B₁₂水平可作为妊高症的预测指标，与妊高症的发生有较好的相关性。

Abstract: Objective To explore the relationship between the serum levels of folic acid and vitamin B12 with pregnancy-induced hypertension (PIH). Methods The serum levels folic acid and vitamin B12 in 25 patients with PIH, 30 normal pregnant women and 35 normal women were measured by chemiluminescent immunoassay (CLIA). Results There is no significant difference of folic acid and vitamin B12 levels between normal pregnant women group and normal women group, the serum folic acid and vitamin B12 levels in patients with PIH were significantly lower than the other two groups (P<0.05). Conclusion The levels of folic acid and vitamin B12 might be used as predictable markers of PIH, there are good correlations between the serum levels of folic acid, vitamin B12 and PIH.