摘要:目的 探讨母血中缺氧诱导因子-1α（HIF-1α）水平及联合胎心监护预测胎儿窘迫的价值。方法 选取40例正常妊娠孕妇（正常妊娠组）及95例胎儿窘迫孕妇（胎儿窘迫组）测定血清HIF-1α水平，同时进行胎心监护分析及新生儿Apgar评分。结果 胎儿窘迫组母血HIF-1α水平为105.73±31.12pg/L，明显高于正常妊娠组（41.48±18.91pg/L）；其中，胎儿窘迫组胎心监护阳性者，母血HIF-1α水平为138.98±30.56 pg/L；可疑者为94.21±28.93 pg/L，两者的HIF-1α水平均明显高于正常妊娠组，差异有统计学意义（P< 0.01）；而胎心监护为阴性者母血HIF-1α水平为47.34±18.76pg/L，与正常妊娠组比较，差异无统计学意义（P>0.05）；在胎儿窘迫三组间，HIF-1α两两比较，差异有统计学意义（P<0.05）。胎儿窘迫组母血HIF-1α水平与新生儿Apgar评分呈负相关。结论 母血HIF-1α水平可作为预测胎儿窘迫的一种新指标，胎心监护联合HIF-1α水平测定可提高判断胎儿宫内缺氧的准确性。

Abstract：Objective To explore the value of detection of hypoxia-inducible factor-1α (HIF-1α) level in maternal blood and fetal heart rate（FHR）monitoring patterns for fetal distress. Methods Ninety five patients with fetal distress (fetal distress group) and 40 healthy pregnant women (control group) were involved in this study. The levels of serum HIF-1α were measured. The fetal heart rate monitoring and the newborn Aparg´s scores were assessed. Results The levels of HIF-1α in maternal blood in fetal distress group were markedly higher than that in control group (105.73±31.12 vs 41.48±18.91 pg/L). In fetal distress group, as for HIF-1α levels in maternal blood, the fetal heart monitoring positive was 138.98±30.56 pg/L, the suspicious person was 94.21±28.93 pg/L, they were all significantly higher than that in the control group（P<0.01）. The fetal heart monitoring negative was 47.34±18.76pg/L. There was no significant difference between the fetal heart monitoring negative and the control group（P>0.05）. A significant difference was found in three groups with the fetal distress（P<0.05）. The level of HIF-1α in maternal blood was negative correlated with newborn Aparg´s score. Conclusion The level of HIF-1α in maternal blood can be used as a new index of predicting fetal distress. The fetal heart monitoring combined determination of HIF-1α could improve the accuracy of assessment of intrauterine fetal anoxia.