目的 了解医院临床分离的145株屎肠球菌和86株粪肠球菌的耐药性。方法 采用法国梅里埃公司的VITEK2 COMPACT全自动微生物分析仪对菌株进行鉴定和抗菌药物敏感性检测。结果 屎肠球菌和粪肠球菌主要来源于尿液（48.92%），其次为血液（12.99%）。屎肠球菌和粪肠球菌对万古霉素、利奈唑烷和替加环素的敏感率均为100%；屎肠球菌除对喹奴普汀/达福普汀和四环素的敏感率显著高于粪肠球菌外，对呋喃妥因、氨苄西林、青霉素G、莫西沙星、环丙沙星、左氧氟沙星的敏感率均显著低于粪肠球菌。结论 屎肠球菌和粪肠球菌对抗菌药物的敏感性存在差异，临床应根据抗菌药物敏感性特征结合种间耐药性差异制定治疗方案。目前万古霉素、利奈唑烷，替加环素为治疗屎肠球菌和粪肠球菌感染的最有效抗菌药物。
Objective To explore the susceptibility of Enterococcus faecium and Enterococcus faecalis isolated from clinical species and provide data for anti-infection therapy. Methods The identification and drug susceptibility of clinical isolates was carried out by using the VITEK2 Compact system, and the results were determined based on the interpretation of CLSI 2012 break point. Results Most of the Enterococcus faecium and Enterococcus faecalis isolated from urine (48.92%) and blood (12.99%). Enterococcus faecalis isolated from different speciemens didn’t have statistical difference from Enterococcus faecium. No strains of vancomycin-, linezolid- and tigecycline-resistant Enterococcus faecium and Enterococcus faecalis were detected. The susceptibility rates of Enterococcus faecium to quinupristin-dalfopristin and tetracycline were higher than that of Enterococcus faecalis. And the susceptibility rates of Enterococcus faecium to nitrofurantoin, ampicillin, penicillin, moxifloxacin, levofloxacin and ciprofloxacin were lower than that of Enterococcus faecalis. Conclusion The drug susceptibility of Enterococcus faecium and Enterococcus faecalis is different. Doctors should choose the proper therapy based on difference of their drug resistance among Enterococcus faecium and Enterococcus faecalis. At present, vancomycin, linezolid and tigecycline are the best choice for treatment against the infection caused by Enterococcus faecium and Enterococcus faecalis.
