目的 为了解β射线治疗增生性瘢痕患者的疗效及肿瘤坏死因子（TNF-α）在照射治疗前、后的动态变化。方法 148例增生性瘢痕患者中84例给予β射线敷贴治疗，40例给予激光治疗，24例不接受任何治疗。记录患者治疗前及治疗第1、2、3个疗程后，疗效及血清TNF-α值。并比较不同组之间治疗效果及TNF-α浓度差异。结果 42例患者经β射线敷贴治疗后治愈率83.3%、有效率100%；对照组治愈率30.0%、有效率55.0%，两组差异有统计学意义(P<0.01)。β射线治疗的患者血清中TNF-a值逐渐下降，差异有统计学意义（P<0.05，P<0.01）。而对照组患者治疗前后血清中TNF-a值无明显变化,差异无统计学意义（P>0.05）。结论 β射线皮肤敷贴器照射能有效地治疗增生性瘢痕。随着增生性瘢痕的治愈，血清TNF-α值逐渐下降，为临床提供有效的理论依据。

Objective To explore the dynamic changes of serum TNF-α in patients with hyperplastic scar before and after β-ray irradiation treatment. Methods 148 patients with hyperplastic scar were involved in this study, 84 cases were given β-ray treatment, 40 cases were given laser treatment, and 24 patients were not received any treatment. The serums TNF-α level for each patient before and after 1, 2 and 3 period of treatment were measured. Results The cure rate in 84 patients and control groups with β-ray treatment were 83.3% and 30.0%; and effective rate were 100% and 55.0%, respectively (P<0.01). The serum TNF-α levels in patients with β-ray treatment were gradually decline and had statistically significant compared with other groups (P<0.05). There was no statistically difference on serum TNF-α levels in control group before and after treatment (P>0.05）. Conclusion The β-ray contact therapy is effective treatment method for hyperplastic scars. The serum TNF-α levels might be used as a clinical indicator of effect judgment in β-ray irradiation treatment of treatment of hyperplastic scars.