目的 了解本地区近两年来不孕不育患者生殖道支原体感染及耐药情况。方法 对2011至2013年在本院生殖门诊就诊并进行支原体培养、鉴定及药敏试验的患者进行统计分析。结果 848份标本中支原体阳性的410份，解脲支原体（Uu）阳性370份。女性患者Uu感染率为45.6%（351/769），男性为24.1% (19/79)。药敏结果显示环丙沙星和氧氟沙星的耐药率分别为89.0%和73.3%，而强力霉素、原始霉素、四环素及交沙霉素的敏感性均达90%以上。结论 本地区不孕不育患者支原体感染率较高，且对环丙沙星及氧氟沙星耐药率较高，但男性与女性感染率有显著差异，临床治疗时必须进行相应的药物敏感性试验，合理选用抗生素，以达到有效治疗的目的。

Objective To investigate the infection of genital tract derived Mycoplasma and antibiotic resistance in local area infertility patients. Methods The mycoplasm from genital tract in patients who had visited and tested in sterility clinic from the year 2011 to 2013 were cultured and identified. The antibiotic resistance was also studied. Results There was 410 positive cases in the 848 samples, and 370 patients were infection by Ureaplasma urealytium (Uu). Uu infection rates in male and female were 45.6% and 24.1%, respectively. The drug resistance rate of ciprofloxacin and ofloxacin were 89.0% and 73.3%, respectively. The drugs with high susceptibility were Doxycycline, Pristinamycin, Tetracycline and Josamycin, the susceptibility rate of these drugs reached more than 90%. Conclusion The genital tract Uu infection rate of infertility patients and the resistance rate of Ciprofloxacin and Ofloxacin are very high in local area. There was a significant difference of infection rates in male and female. The clinic treatment should be based on the drug sensitivity test results.