目的 探讨腹型肥胖患者obestatin的血浆水平及与腰围的相关性。方法 入选腹型肥胖组患者50例（男性腰围≥85cm，女性腰围≥80cm），及正常对照组20例（男性腰围<85cm，女性腰围<80cm，24 kg/m2＞BMI≥18.5 kg/m2）。应用放射免疫分析法测定血浆obestatin及血清胰岛素水平。血清血脂水平采用自动生化分析仪进行酶法测定。胰岛素抵抗采用胰岛素抵抗指数（HOMA-IR）评定。结果 腹型肥胖个体均表现出高的HOMA-IR、血清胆固醇及甘油三酯水平及低的高密度脂蛋白水平。与正常对照组相比，腹型肥胖组个体的血浆obestatin水平有所下降。在腹型肥胖的个体中，血浆obestatin水平与腰围及体重指数呈负相关。结论 腹型肥胖组的血浆 obestatin水平明显降低，而且obestatin水平与腰围呈负相关，提示obestatin与脂肪分布及腹型肥胖的发生有关。
Objective To explore the relationship between plasma obestatin concentrations in abdominal obesity subjects and waist circumference (WC). Methods The present study comprised 2 groups, 50 Chinese abdominal obesity subjects (waist circumference of men ≥85cm，waist circumference of women ≥80cm), 20 age-matched normal subjects (waist circumference of men <85cm，waist circumference of women <80cm，BMI ≥24kg/m2）were included. The fasting plasma levels of obestatin and insulin were measured by RIA. Insulin resistance was calculated by the homeostasis model of assessment for insulin resistance (HOMA-IR) approach. Results Subjects with abdominal obesity displayed higher HOMA-IR, serum total cholesterol and triglyceride compared to normal control. The plasma obestatin concentrations in abdominal obesity group were lower compared to normal control. The plasma obestatin concentrations in abdominal obesity subjects were negatively related with WC and BMI. Conclusion The results in this study indicate that the obestatin might be important in distribution of body fat and development of abdominal obesity.
