目的 通过研究AKT-1在乳腺癌、癌旁正常组织、乳腺纤维腺瘤中的表达情况,探讨其在乳腺癌评估预后及治疗方面的价值。方法 采用免疫组化SP法，检测61例乳腺癌、20例癌旁正常组织、20例乳腺纤维腺瘤中AKT-1的表达情况。 结果 AKT-1在乳腺癌旁正常组织中无表达,在纤维腺瘤中低表达（阳性率为15% )，在乳腺癌组织中高表达（阳性率为 49. 2% )，差异具有统计学意义(P<0.05)。在乳腺癌组中,AKT-1的阳性表达率与HER-2表达情况呈正相关;在原发灶大小不同、腋窝淋巴结有无转移和TNM分期不同组中，AKT-1的阳性表达率差异有统计学意义（P <0.05);在不同年龄、 不同雌孕激素受体情况和不同组织学类型中，差异无统计学意义（P>0.05)。结论 AKT-1可能是导致乳腺癌发生、发展的因素之一，在乳腺癌细胞向周围组织浸润，远处转移中起一定作用，对判断乳腺癌的恶性程度及预后有重要意义。

Objective To explore the clinical values of AKT-1 in assessment of prognosis and treatment of breast carcinoma. Methods The expression of AKT-1 in 20 cases of peritumoral tissue ,20 cases of breast fibroadenoma and 61 cases of breast cancer were detected by immumohistochemical technique S-P. All the data were analyzed by using SPSS 17. 0. Results There was no expression of AKT-1 in normal mammary gland. There was a significant difference in the positive rates for expression of AKT-1 between the fibroadenoma and breast cancer (P < 0. 05 ) . The positive expression rate of AKT-1 in breast cancer group had significant difference based on the sizes of the primary tumor，lymph node metastasis and different stages of TMN ( P < 0. 05 ) . The positive expression of AKT-1 had no difference between different ages，hormone receptors and histological types ( P > 0. 05) . Conclusion AKT-1 plays an important role in promoting the process and invasion and metastasis of breast cancer，it could be used as one of indicators in evaluating prognosis of breast carcinoma.