Abstract：Objective To explore the influence of irbesartan on the expression of myocardial TGF-β1 and CTGF in type 2 diabetic rats. Methods The blood glucose，insulin, body weight, and heart weight index in type 2 diabetic rats and healthy controls were determined. The expression of myocardium TGF- beta 1 and CTGF in type 2 diabetic rats after treated with irbesartan were analyzed Results There were significantly difference on body weight, heart weight index, blood glucose and insulin between type 2 diabetic rats with and without irbesartan treatment (P < 0.05). The expression of TGF-β1 and CTGF in type 2 diabetic rats with irbesartan intervention were statistical lower that of without irbesartan intervention (P < 0.05). Conclusion Irbesartan could have a protective effect on myocardial tissue of type 2 diabetic rats, and it is worth for further study.