Objective To observe the effects of BushentiaoganQingxin decoction on sex hormone and serum IL-1 β, IL-2 and IL6 level in perimenopausal depression model rats. Methods 60 perimenopausal rats were randomly divided into 5 groups, including normal group, perimenopausal depression sleep disorder model group, perimenopausal depression sleep disorder progynova treatment group, perimenopausal depression sleep disorder mirtazapine treatment group, and perimenopausal depression sleep disorder TCM treatment group. After the last administration, the rats were killed by cervical dislocation. The serum levels of E2, LH, FSH, IL-1 β, IL-2 and IL-6 in each group rats were detected by RIA and ELISA. Results The serum E2 level in perimenopausal depression treatment group was higher than that of the normal group and the model group, and progynova and TCM medicine group compared with the model group（P<0.05）. The FSH levels in treatment group was lower than that of the normal group and the model group, and mirtazapine and TCM medicine group compared with model group (P<0.05). The LH levels of the progynova and mirtazapine group were significantly lower than that of model group (P<0.05). The serum levels of IL-2, IL-6 and IL-1 β in perimenopause rats model of depression was significantly lower than that of normal control group (P<0.05). Progynova, mirtazapine and TCM could increase the serum IL-2 and IL-6 level compared with the model group (P<0.05). Conclusion The serum IL-2, IL-6 and IL-1 β levels in the rats model group was lower; BushentiaoganQingxin decoction may treat perimenopausal depression through increasing the serum E2, IL2 and IL-6 level and decreasing the serum FSH and LH level.