Objective To assess whether serum oxidized lipoprotein(a) [ox-Lp(a)] and the complex of β2-glycoprotein I with ox-Lp(a) [β2-GPI-Lp(a)] levels are elevated after percutaneous coronary intervention (PCI) and whether can be used as additional inflammatory factors to reflect the oxidative stress state during PCI. Methods Serum samples were collected from 60 patients with coronary heart disease (CHD) before and within three days after PCI. In addition, serum samples were also collected from 35 non-CHD individuals before and after coronary arteriongraphy (CAG). Serum levels of ox-Lp (a) and β2-GPI-Lp (a) were measured with sandwich ELISAs. Some other traits including serum lipids and high-sensitivity C-reactive protein (hs-CRP）were also were measured. Results The serum hs-CRP levels in CHD patients after PCI were significantly elevated as compared with those before PCI (9.31±8.22 mg/L vs 4.96±5.57mg/L, P<0.05).The serum concentrations of ox-Lp(a) and β2-GPI-ox-Lp(a) were also markedly increased (10.51±9.39 mg/L vs 7.38±6.65 mg/L，P<0.05; 1.70±2.37 U/mL vs 0.91±1.07 U/mL, P<0.05, respectively). While routine serum lipids levels did not display marked change after PCI. Both the serum ox-Lp(a) and β2-GPI-ox-Lp(a) concentrations in CHD patients were significantly positively correlated with the percentage of diameter of stenosis and number of vessel disease. β2-GPI-ox-Lp(a) was positively correlated with ox-Lp(a) in CHD patients either before or after PCI (P = 0.0001). In addition, CAG also resulted in the elevation of β2-GPI-ox-Lp (a) levels. Conclusion The serum ox-Lp (a) and β2-GPI-ox-Lp (a) concentration were increased in CHD patients after PCI, suggesting that measurement of these two traits together with hs-CRP might be useful as in monitoring the inflammation and oxidative stress state during PCI.