目的通过对13452例人乳头瘤病毒(HPV)亚型感染检测结果的分析，了解检测样本的HPV感染状况及年龄分布特点。方法采用导流杂交技术检测21种HPV亚型，包括14种高危型和7种低危型HPV，分析受检妇女中常见的HPV亚型感染及分布规律。结果HPV亚型感染总阳性率为36.98%，21种亚型被检出。高危型以HPV16最为常见，低危型最常见为HPV53。HPV多重感染比例为24.08%，以二重感染最为多见。结论13452例受检妇女HPV亚型感染总阳性率为36.98%，常见的3种高危型为HPV16、HPV58、HPV52，2种低危型为HPV53和HPVcp8304。19~29岁年龄组，≥60岁年龄组的HPV亚型感染阳性率和HPV多重感染阳性率表现出较弱的高峰，HPV多重感染以二重感染最多见。
Objective To evaluate the genotype and age distribution of human genotype papilloma virus (HPV) infection in 13452 cases. Methods The 21different genotypes including 14 high-risk genotypes and 7 low-risk genotypes of HPV in 13452 cases were detected by flow through tybridization. Results The total positive rate of HPV infection was 36.98%. All 21different genotypes were found. The most common high-risk genotype and low-risk genotype was HPV16 and HPV53, respectively. The multiple infection rate was 24.08% and two co-infections were the most common situation. Conclusion The 3 most common high-risk genotypes of HPV infection are HPV16, 58, 52,and the 2 most common low-risk are HPV53 and cp8304. The infection peak age is 19 to 29 years old and ≥60 years old. Two types co-infection are the most common multiple HPV infection.
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