摘 要：目的  探讨智能分光比色内镜 (Fuji Intelligent Chromo Endoscope，FICE)、胃蛋白酶原Ⅰ(pepsinogen I，PGⅠ）、胃蛋白酶原Ⅱ（Pepsinogen Ⅱ,PGⅡ）对胃癌及萎缩性胃炎的诊断价值。方法  随机选取2013年10月至2014年9月于我院进行治疗的160例胃癌（gastric carcinoma, GC）患者及200例萎缩性胃炎（chronic atrophic gastritis，CAG）患者。采用酶联免疫法（ELISA）检测以上患者及100例正常人的PGⅠ、PGⅡ水平及PGR（PGⅠ/ PGⅡ ratio）变化。将360例患者随机分为两组，白光内镜组及FICE内镜组，分别180例。所有患者再次进行胃镜检查，白光内镜组不染色而仅肉眼观测常规取活检；FICE内镜组在FICE内镜下染色后在可疑病灶处取活检。结果  与正常人比较，GC、CAG患者的PGⅠ及PGR水平显著降低，差异具有统计学意义（P<0.01），PGⅡ水平比较差异不具有统计学意义（P>0.05）；GC组和CAG组PG异常检出比例显著高于健康组，差异具有统计学意义（P<0.01）； FICE内镜组阳性检出率（93.3%）显著高于白光内镜组（61.7%），两组比较差异具有统计学意义（P<0.01）。结论： FICE内镜较白光内镜检出率更高，FICE内镜联合胃蛋白酶原Ⅰ、胃蛋白酶原Ⅱ水平检测可进一步提高胃癌及萎缩性胃炎的检出率，有助于早期筛查及预防，具有非常重要的临床价值。

Abstract: Objective To evaluate the value of combined FICE and detection of PepsinogenⅠand PepsinogenⅡ in diagnosis of gastric carcinoma (GC) and chronic atrophic gastritis (CAG). Methods 160 cases of GC patients and 200 cases of CAG patients treated in our hospital were randomly chosen. The levels of PG, PGⅡand PGR were measured with ELASA in these 360 patients and 100 healthy controls. The 360 patients were randomized into two groups, normal endoscope group and FICE group. Patients in normal endoscope group just were inspected with normal endoscope; While Patients in FICE group were performed with FICE gastric endoscope. Results The Gland PGR level in GC patients and CAG patients were significantly lower than those of the healthy people (P<0.01), there was no significant difference in PGⅡlevel between the patients and healthy people. The abnormal rate of PG in GC patients and CAG patients were significantly higher than that of the healthy people (P<0.01). The positive rate detected in FICE group was significantly higher than that of normal endoscope group (P<0.01).Conclusion The positive detection rate of FICE endoscope is higher than that of white light endoscope. The combined FICE and detection of PepsinogenⅠand PepsinogenⅡ could be very helpful for further improving the positive detection rate of GC and CAG, and used for the early screening and prevention of gastric disease.